IBBR Publications

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Tong Z, Schiel JE, Papastavros E, Ohnmacht CM, Smith QR, Hage DS. Kinetic studies of drug-protein interactions by using peak profiling and high-performance affinity chromatography: examination of multi-site interactions of drugs with human serum albumin columns. J Chromatogr A. 2011 ;1218(15):2065-71.
Li Y, O'Dell S, Walker LM, Wu X, Guenaga J, Feng Y, Schmidt SD, McKee K, Louder MK, Ledgerwood JE, et al. Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01. J Virol. 2011 ;85(17):8954-67.
Cramer WA, Zakharov SD, S Hasan S, Zhang H, Baniulis D, Zhalnina MV, Soriano GM, Sharma O, Rochet JC, Ryan C, et al. Membrane proteins in four acts: function precedes structure determination. Methods. 2011 ;55(4):415-20.
Calderon AJ, Bhowmick T, Leferovich J, Burman B, Pichette B, Muzykantov V, Eckmann DM, Muro S. Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. J Control Release. 2011 ;150(1):37-44.
Gorlatova N, Chao K, Pal LR, Araj RHanna, Galkin A, Turko IV, Moult J, Herzberg O. Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitution. PLoS One. 2011 ;6(11):e27269.
Liao W-L, Heo G-Y, Dodder NG, Reem RE, Mast N, Huang S, Dipatre PLuigi, Turko IV, Pikuleva IA. Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain. J Proteome Res. 2011 ;10(1):241-8.
Lowenthal MS, Gasca-Aragon H, Schiel JE, Dodder NG, Bunk DM. A quantitative LC-MS/MS method for comparative analysis of capture-antibody affinity toward protein antigens. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 ;879(26):2726-32.
Acharya C, Coop A, Polli JE, Mackerell AD. Recent advances in ligand-based drug design: relevance and utility of the conformationally sampled pharmacophore approach. Curr Comput Aided Drug Des. 2011 ;7(1):10-22.
Yap JL, Worlikar S, Mackerell AD, Shapiro P, Fletcher S. Small-molecule inhibitors of the ERK signaling pathway: Towards novel anticancer therapeutics. ChemMedChem. 2011 ;6(1):38-48.
Shi Z, Moult J. Structural and functional impact of cancer-related missense somatic mutations. J Mol Biol. 2011 ;413(2):495-512.
Darian E, Guvench O, Yu B, Qu C-K, Mackerell AD. Structural mechanism associated with domain opening in gain-of-function mutations in SHP2 phosphatase. Proteins. 2011 ;79(5):1573-88.
Yin Y, Li Y, Kerzic MC, Martin R, Mariuzza RA. Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection. EMBO J. 2011 ;30(6):1137-48.
Li Y, Wang Q, Mariuzza RA. Structure of the human activating natural cytotoxicity receptor NKp30 bound to its tumor cell ligand B7-H6. J Exp Med. 2011 ;208(4):703-14.
Chen C, Gorlatova N, Kelman Z, Herzberg O. Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements. Proc Natl Acad Sci U S A. 2011 ;108(16):6456-61.
Bruno RD, Vasaitis TS, Gediya LK, Purushottamachar P, Godbole AM, Ates-Alagoz Z, Brodie AMH, Njar VCO. Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model. Steroids. 2011 ;76(12):1268-79.
Kryshtafovych A, Moult J, Bartual SG, J Bazan F, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, et al. Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins. 2011 ;79 Suppl 10:6-20.
Xu Z, Chen Y-W, Battu A, Wilder PT, Weber DJ, Yu W, Mackerell AD, Chen L-M, Chai KX, Johnson MD, et al. Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade. J Med Chem. 2011 ;54(21):7567-78.
House RP, Pozzuto M, Patel P, Dulyaninova NG, Li Z-H, Zencheck WD, Vitolo MI, Weber DJ, Bresnick AR. Two functional S100A4 monomers are necessary for regulating nonmuscle myosin-IIA and HCT116 cell invasion. Biochemistry. 2011 ;50(32):6920-32.
Zucconi BE, Ballin JD, Brewer BY, Ross CR, Huang J, Toth EA, Wilson GM. Alternatively expressed domains of AU-rich element RNA-binding protein 1 (AUF1) regulate RNA-binding affinity, RNA-induced protein oligomerization, and the local conformation of bound RNA ligands. J Biol Chem. 2010 ;285(50):39127-39.
Liu Y, Kim E, Ghodssi R, Rubloff GW, Culver JN, Bentley WE, Payne GF. Biofabrication to build the biology-device interface. Biofabrication. 2010 ;2(2):022002.
Hebert CG, Gupta A, Fernandes R, Tsao C-Y, Valdes JJ, Bentley WE. Biological nanofactories target and activate epithelial cell surfaces for modulating bacterial quorum sensing and interspecies signaling. ACS Nano. 2010 ;4(11):6923-31.
Walsh STR. A biosensor study indicating that entropy, electrostatics, and receptor glycosylation drive the binding interaction between interleukin-7 and its receptor. Biochemistry. 2010 ;49(40):8766-78.
Lin J, Yang Q, Wilder PT, Carrier F, Weber DJ. The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma. J Biol Chem. 2010 ;285(35):27487-98.
Gilquin B, Cannon BR, Hubstenberger A, Moulouel B, Falk E, Merle N, Assard N, Kieffer S, Rousseau D, Wilder PT, et al. The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A. Mol Cell Biol. 2010 ;30(11):2724-36.
Pierce BG, Haidar JN, Yu Y, Weng Z. Combinations of affinity-enhancing mutations in a T cell receptor reveal highly nonadditive effects within and between complementarity determining regions and chains. Biochemistry. 2010 ;49(33):7050-9.