IBBR Publications

Padia J, Kulakova L, Galkin A, Herzberg O. Discovery and Preclinical Development of Antigiardiasis Fumagillol Derivatives. Antimicrob Agents Chemother. 2020 ;64(10).

Chao KL, Kulakova L, Herzberg O. Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein. Proc Natl Acad Sci U S A. 2017 ;114(7):E1128-E1137.

Kulakova L, Galkin A, Chen CZ, Southall N, Marugan JJ, Zheng W, Herzberg O. Discovery of Novel Antigiardiasis Drug Candidates. Antimicrob Agents Chemother. 2014 .

Galkin A, Kulakova L, Lim K, Chen CZ, Zheng W, Turko IV, Herzberg O. Structural Basis for Inactivation of Giardia lamblia Carbamate Kinase by Disulfiram. J Biol Chem. 2014 .

Lim K, Kulakova L, Galkin A, Herzberg O. Crystal structures of carbamate kinase from Giardia lamblia bound with citric acid and AMP-PNP. PLoS One. 2013 ;8(5):e64004.

Chen CZ, Kulakova L, Southall N, Marugan JJ, Galkin A, Austin CP, Herzberg O, Zheng W. High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements. Antimicrob Agents Chemother. 2011 ;55(2):667-75.

Galkin A, Kulakova L, Wu R, Nash TE, Dunaway-Mariano D, Herzberg O. X-ray structure and characterization of carbamate kinase from the human parasite Giardia lamblia. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 ;66(Pt 4):386-90.

Galkin A, Li Z, Li L, Kulakova L, Pal LR, Dunaway-Mariano D, Herzberg O. Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase. Biochemistry. 2009 ;48(14):3186-96.

Galkin A, Kulakova L, Wu R, Gong M, Dunaway-Mariano D, Herzberg O. X-ray structure and kinetic properties of ornithine transcarbamoylase from the human parasite Giardia lamblia. Proteins. 2009 ;76(4):1049-53.

Galkin A, Kulakova L, Melamud E, Li L, Wu C, Mariano P, Dunaway-Mariano D, Nash TE, Herzberg O. Characterization, kinetics, and crystal structures of fructose-1,6-bisphosphate aldolase from the human parasite, Giardia lamblia. J Biol Chem. 2007 ;282(7):4859-67.

Galkin A, Kulakova L, Sarikaya E, Lim K, Howard A, Herzberg O. Structural insight into arginine degradation by arginine deiminase, an antibacterial and parasite drug target. J Biol Chem. 2004 ;279(14):14001-8.