IBBR Publications

Found 22 results
Filters: Author is He, Yanan  [Clear All Filters]
2021
Chen Y, Toth EA, Ruan B, Choi EJung, Simmerman R, Chen Y, He Y, Wang R, Godoy-Ruiz R, King H, et al. Engineering subtilisin proteases that specifically degrade active RAS. Commun Biol. 2021 ;4(1):299.
2020
He Y, Agnihotri P, Rangarajan S, Chen Y, Kerzic MC, Ma B, Nussinov R, Mariuzza RA, Orban J. Peptide-MHC Binding Reveals Conserved Allosteric Sites in MHC Class I- and Class II-Restricted T Cell Receptors (TCRs). J Mol Biol. 2020 ;432(24):166697.
2019
Lin X, Kulkarni P, Bocci F, Schafer NP, Roy S, Tsai M-Y, He Y, Chen Y, Rajagopalan K, Mooney SM, et al. Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level. Biomolecules. 2019 ;9(2).
2018
Lin X, Roy S, Jolly MKumar, Bocci F, Schafer NP, Tsai M-Y, Chen Y, He Y, Grishaev A, Weninger K, et al. PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer. J Mol Biol. 2018 .
Rangarajan S, He Y, Chen Y, Kerzic MC, Ma B, Gowthaman R, Pierce BG, Nussinov R, Mariuzza RA, Orban J. Peptide-MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites. J Biol Chem. 2018 .
Kulkarni P, Solomon T, He Y, Chen Y, Bryan PN, Orban J. Structural metamorphism and polymorphism in proteins on the brink of thermodynamic stability. Protein Sci. 2018 .
2017
Kulkarni P, Jolly MKumar, Jia D, Mooney SM, Bhargava A, Kagohara LT, Chen Y, Hao P, He Y, Veltri RW, et al. Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity. Proc Natl Acad Sci U S A. 2017 .
2015
He Y, Rangarajan S, Kerzic M, Luo M, Chen Y, Wang Q, Yin Y, Workman CJ, Vignali KM, Vignali DAA, et al. Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR. J Biol Chem. 2015 .
He Y, Chen Y, Mooney SM, Rajagopalan K, Bhargava A, Sacho E, Weninger K, Bryan PN, Kulkarni P, Orban J. Phosphorylation-Induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen. J Biol Chem. 2015 .
Porter LL, He Y, Chen Y, Orban J, Bryan PN. Subdomain Interactions Foster the Design of Two Protein Pairs with ∼80% Sequence Identity but Different Folds. Biophys J. 2015 ;108(1):154-62.
2012
He Y, Chen Y, Alexander PA, Bryan PN, Orban J. Mutational tipping points for switching protein folds and functions. Structure. 2012 ;20(2):283-91.
He Y, Chen Y, Oganesyan N, Ruan B, O'Brochta DA, Bryan PN, Orban J. Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum. Proteins. 2012 ;80(12):2810-7.
2011
Zeng Y, He Y, Yang F, Mooney SM, Getzenberg RH, Orban J, Kulkarni P. The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein. J Biol Chem. 2011 ;286(16):13985-94.
2010
Shen Y, Bryan PN, He Y, Orban J, Baker D, Bax A. De novo structure generation using chemical shifts for proteins with high-sequence identity but different folds. Protein Sci. 2010 ;19(2):349-56.
2009
Alexander PA, He Y, Chen Y, Orban J, Bryan PN. A minimal sequence code for switching protein structure and function. Proc Natl Acad Sci U S A. 2009 ;106(50):21149-54.
2008
He Y, Chen Y, Alexander P, Bryan PN, Orban J. NMR structures of two designed proteins with high sequence identity but different fold and function. Proc Natl Acad Sci U S A. 2008 ;105(38):14412-7.
2007
He Y, Chen Y, Rozak DA, Bryan PN, Orban J. An artificially evolved albumin binding module facilitates chemical shift epitope mapping of GA domain interactions with phylogenetically diverse albumins. Protein Sci. 2007 ;16(7):1490-4.
Alexander PA, He Y, Chen Y, Orban J, Bryan PN. The design and characterization of two proteins with 88% sequence identity but different structure and function. Proc Natl Acad Sci U S A. 2007 ;104(29):11963-8.
Sari N, He Y, Doseeva V, Surabian K, Ramprakash J, Schwarz FP, Herzberg O, Orban J. Solution structure of HI1506, a novel two-domain protein from Haemophilus influenzae. Protein Sci. 2007 ;16(5):977-82.
2006
He Y, Rozak DA, Sari N, Chen Y, Bryan PN, Orban J. Structure, dynamics, and stability variation in bacterial albumin binding modules: implications for species specificity. Biochemistry. 2006 ;45(33):10102-9.
Rozak DA, Alexander PA, He Y, Chen Y, Orban J, Bryan PN. Using offset recombinant polymerase chain reaction to identify functional determinants in a common family of bacterial albumin binding domains. Biochemistry. 2006 ;45(10):3263-71.
2005
He Y, Yeh DCheon, Alexander P, Bryan PN, Orban J. Solution NMR structures of IgG binding domains with artificially evolved high levels of sequence identity but different folds. Biochemistry. 2005 ;44(43):14055-61.