Publications

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SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors.
Choy C, Chen J, Li J, Gallagher DT, Lu J, Wu D, Zou A, Hemani H, Baptiste BA, Wichmann E, et al. 2023. SARS-CoV-2 infection establishes a stable and age-independent CD8+ T cell response against a dominant nucleocapsid epitope using restricted T cell receptors. Nature communications 14(1): 6725. DOI: 10.1038/s41467-023-42430-z
Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir.
Prévost J, Chen Y, Zhou F, Tolbert WD, Gasser R, Medjahed H, Nayrac M, Nguyen DN, Gottumukkala S, Hessell AJ, et al. 2023. Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir. Nature communications 14(1): 6710. DOI: 10.1038/s41467-023-42500-2
Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2.
Lázaro-Gorines R, Pérez P, Heras-Murillo I, Adán-Barrientos I, Albericio G, Astorgano D, Flores S, Luczkowiak J, Labiod N, Harwood SL, et al. 2023. Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2. Advanced science (Weinheim, Baden-Wurttemberg, Germany) : e2304818. DOI: 10.1002/advs.202304818
Non-β Lactam Inhibitors of the Serine β-Lactamase blaCTX-M15 in Drug-Resistant Salmonella typhi.
Ahmad F, Parvaiz N, MacKerell AD, Azam SS. 2023. Non-β Lactam Inhibitors of the Serine β-Lactamase blaCTX-M15 in Drug-Resistant <i>Salmonella typhi</i>. Journal of chemical information and modeling : . DOI: 10.1021/acs.jcim.3c00780
Monitoring Protein Complexation with Polyphosphazene Polyelectrolyte Using Automated Dynamic Light Scattering Titration and Asymmetric Flow Field Flow Fractionation and Protein Recognition Immunoassay.
Lueckheide M, Marin A, Tagad HD, Posey ND, Prabhu VM, Andrianov AK. 2023. Monitoring Protein Complexation with Polyphosphazene Polyelectrolyte Using Automated Dynamic Light Scattering Titration and Asymmetric Flow Field Flow Fractionation and Protein Recognition Immunoassay. ACS polymers Au 3(5): 354-364. DOI: 10.1021/acspolymersau.3c00006
A unique borrelial protein facilitates microbial immune evasion.
Foor SD, Brangulis K, Shakya AK, Rana VS, Bista S, Kitsou C, Ronzetti M, Alreja AB, Linden SB, Altieri AS, et al. 2023. A unique borrelial protein facilitates microbial immune evasion. mBio : e0213523. DOI: 10.1128/mbio.02135-23
Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer.
Mohanty A, Nam A, Srivastava S, Jones J, Lomenick B, Singhal SS, Guo L, Cho H, Li A, Behal A, et al. 2023. Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer. Science advances 9(41): eade3816. DOI: 10.1126/sciadv.ade3816
Lysosomal Therapies and Drug Delivery Strategies: An Overview.
Muro S. 2023. Lysosomal Therapies and Drug Delivery Strategies: An Overview. Advanced drug delivery reviews : 115112. DOI: 10.1016/j.addr.2023.115112
Zika virus NS4B protein targets TANK-binding kinase 1 and inhibits type I interferon production.
Sarratea MB, Alberti AS, Redolfi DM, Truant SN, Iannantuono Lopez LV, Bivona AE, Mariuzza RA, Fernández MM, Malchiodi EL. 2023. Zika virus NS4B protein targets TANK-binding kinase 1 and inhibits type I interferon production. Biochimica et biophysica acta. General subjects : 130483. DOI: 10.1016/j.bbagen.2023.130483
Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation.
Lee YS, Cheng IT, Raquel GR, Weber DJ, Scalea JR. 2023. Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation. Innate immunity 29(7): 150-158. DOI: 10.1177/17534259231186239
Mutation and Selection Induce Correlations between Selection Coefficients and Mutation Rates.
Gitschlag BL, Cano AV, Payne JL, McCandlish DM, Stoltzfus A. 2023. Mutation and Selection Induce Correlations between Selection Coefficients and Mutation Rates. The American naturalist 202(4): 534-557. DOI: 10.1086/726014
Immunogenic epitope scanning in bacteriolytic enzymes Pal and Cpl-1 and engineering Pal to escape antibody responses.
Harhala MA, Gembara K, Rybicka I, Kaźmierczak ZM, Miernikiewicz P, Majewska JM, Budziar W, Nasulewicz-Goldeman A, Nelson DC, Owczarek B, et al. 2023. Immunogenic epitope scanning in bacteriolytic enzymes Pal and Cpl-1 and engineering Pal to escape antibody responses. Frontiers in immunology 14: 1075774. DOI: 10.3389/fimmu.2023.1075774
VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2.
Thankan RS, Thomas E, Purushottamachar P, Weber DJ, Ramamurthy VP, Huang W, Kane MA, Njar VCO. 2023. VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins <i>in vitro</i> and <i>in vivo</i> by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2. Frontiers in oncology 13: 1240996. DOI: 10.3389/fonc.2023.1240996
Role of the Lactide:Glycolide Ratio in PLGA Nanoparticle Stability and Release under Lysosomal Conditions for Enzyme Replacement Therapy of Lysosomal Storage Disorders.
Del Moral M, Loeck M, Muntimadugu E, Vives G, Pham V, Pfeifer P, Battaglia G, Muro S. 2023. Role of the Lactide:Glycolide Ratio in PLGA Nanoparticle Stability and Release under Lysosomal Conditions for Enzyme Replacement Therapy of Lysosomal Storage Disorders. Journal of functional biomaterials 14(9): . DOI: 10.3390/jfb14090440
Role of Domain-Domain Interactions on the Self-Association and Physical Stability of Monoclonal Antibodies: Effect of pH and Salt.
Xu AY, Blanco MA, Castellanos MM, Meuse CW, Mattison K, Karageorgos I, Hatch HW, Shen VK, Curtis JE. 2023. Role of Domain-Domain Interactions on the Self-Association and Physical Stability of Monoclonal Antibodies: Effect of pH and Salt. The journal of physical chemistry. B : . DOI: 10.1021/acs.jpcb.3c03928