IBBR Publications

Found 36 results
Filters: Keyword is Phosphorylation  [Clear All Filters]
2015
Venditti V, Schwieters CD, Grishaev A, G Clore M. Dynamic equilibrium between closed and partially closed states of the bacterial Enzyme I unveiled by solution NMR and X-ray scattering. Proc Natl Acad Sci U S A. 2015 ;112(37):11565-70.
Samadani R, Zhang J, Brophy A, Oashi T, U Priyakumar D, E Raman P, St John FJ, Jung K-Y, Fletcher S, Pozharski E, et al. Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf. Biochem J. 2015 ;467(3):425-38.
2014
Li T, Yang D, Zhong S, Thomas JM, Xue F, Liu J, Kong L, Voulalas P, Hassan HE, Park J-S, et al. Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models. Hum Mol Genet. 2014 ;23(23):6212-22.
2012
Chen J, Wang M, Turko IV. Mass spectrometry quantification of clusterin in the human brain. Mol Neurodegener. 2012 ;7:41.
2011
Boston SR, Deshmukh R, Strome S, U Priyakumar D, Mackerell AD, Shapiro P. Characterization of ERK docking domain inhibitors that induce apoptosis by targeting Rsk-1 and caspase-9. BMC Cancer. 2011 ;11:7.
Takayama Y, Schwieters CD, Grishaev A, Ghirlando R, G Clore M. Combined use of residual dipolar couplings and solution X-ray scattering to rapidly probe rigid-body conformational transitions in a non-phosphorylatable active-site mutant of the 128 kDa enzyme I dimer. J Am Chem Soc. 2011 ;133(3):424-7.
Li S. Smallest genetically encoded phosphorylation status sensor. Chembiochem. 2011 ;12(18):2729-31.
2010
Lin J, Yang Q, Wilder PT, Carrier F, Weber DJ. The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma. J Biol Chem. 2010 ;285(35):27487-98.
Roy V, Fernandes R, Tsao C-Y, Bentley WE. Cross species quorum quenching using a native AI-2 processing enzyme. ACS Chem Biol. 2010 ;5(2):223-32.
Zhang J, Wang Y, Li S. Deuterium isobaric amine-reactive tags for quantitative proteomics. Anal Chem. 2010 ;82(18):7588-95.
Schwieters CD, Suh J-Y, Grishaev A, Ghirlando R, Takayama Y, G Clore M. Solution structure of the 128 kDa enzyme I dimer from Escherichia coli and its 146 kDa complex with HPr using residual dipolar couplings and small- and wide-angle X-ray scattering. J Am Chem Soc. 2010 ;132(37):13026-45.
Li Y, Depontieu FR, Sidney J, Salay TM, Engelhard VH, Hunt DF, Sette A, Topalian SL, Mariuzza RA. Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells. J Mol Biol. 2010 ;399(4):596-603.
Mittag T, Marsh J, Grishaev A, Orlicky S, Lin H, Sicheri F, Tyers M, Forman-Kay JD. Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase. Structure. 2010 ;18(4):494-506.
Roy V, Smith JAI, Wang J, Stewart JE, Bentley WE, Sintim HO. Synthetic analogs tailor native AI-2 signaling across bacterial species. J Am Chem Soc. 2010 ;132(32):11141-50.
2008
Bruno RD, Gover TD, Burger AM, Brodie AM, Njar VCO. 17alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response. Mol Cancer Ther. 2008 ;7(9):2828-36.
Garnacho C, Shuvaev V, Thomas A, McKenna L, Sun J, Koval M, Albelda S, Muzykantov V, Muro S. RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1. Blood. 2008 ;111(6):3024-33.
2006
Wilder PT, Lin J, Bair CL, Charpentier TH, Yang D, Liriano M, Varney KM, Lee A, Oppenheim AB, Adhya S, et al. Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B. Biochim Biophys Acta. 2006 ;1763(11):1284-97.
Guo Z, Dai B, Jiang T, Xu K, Xie Y, Kim O, Nesheiwat I, Kong X, Melamed J, Handratta VD, et al. Regulation of androgen receptor activity by tyrosine phosphorylation. Cancer Cell. 2006 ;10(4):309-19.
Teplyakov A, Lim K, Zhu P-P, Kapadia G, Chen CCH, Schwartz J, Howard A, Reddy PT, Peterkofsky A, Herzberg O. Structure of phosphorylated enzyme I, the phosphoenolpyruvate:sugar phosphotransferase system sugar translocation signal protein. Proc Natl Acad Sci U S A. 2006 ;103(44):16218-23.
Unger R, Moult J. Towards computing with proteins. Proteins. 2006 ;63(1):53-64.
2005
Hancock CN, Macias A, Lee EKyoung, Yu SYeon, Mackerell AD, Shapiro P. Identification of novel extracellular signal-regulated kinase docking domain inhibitors. J Med Chem. 2005 ;48(14):4586-95.
Kasiviswanathan R, Shin J-H, Kelman Z. Interactions between the archaeal Cdc6 and MCM proteins modulate their biochemical properties. Nucleic Acids Res. 2005 ;33(15):4940-50.
Chen Y-J, Yu X, Kasiviswanathan R, Shin J-H, Kelman Z, Egelman EH. Structural polymorphism of Methanothermobacter thermautotrophicus MCM. J Mol Biol. 2005 ;346(2):389-94.
2004
Huang N, Nagarsekar A, Xia G, Hayashi J, Mackerell AD. Identification of non-phosphate-containing small molecular weight inhibitors of the tyrosine kinase p56 Lck SH2 domain via in silico screening against the pY + 3 binding site. J Med Chem. 2004 ;47(14):3502-11.
Cho S, Velikovsky CA, Swaminathan CP, Houtman JCD, Samelson LE, Mariuzza RA. Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. EMBO J. 2004 ;23(7):1441-51.