IBBR Publications

Mistry P, Laird MHW, Schwarz RS, Greene S, Dyson T, Snyder GA, Xiao TSam, Chauhan J, Fletcher S, Toshchakov VY, et al. Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain. Proc Natl Acad Sci U S A. 2015 ;112(17):5455-60.

Wu EL, Qi Y, Park S, Mallajosyula SS, Mackerell AD, Klauda JB, Im W. Insight into Early-Stage Unfolding of GPI-Anchored Human Prion Protein. Biophys J. 2015 ;109(10):2090-100.

Domene C, Jorgensen C, Vanommeslaeghe K, Schofield CJ, Mackerell AD. Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor. J Chem Theory Comput. 2015 ;11(8):3946-54.

Trastoy B, Lomino JV, Pierce BG, Carter LG, Günther S, Giddens JP, Snyder GA, Weiss TM, Weng Z, Wang L-X, et al. Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies. Proc Natl Acad Sci U S A. 2014 ;111(18):6714-9.

S Hasan S, Cramer WA. Internal lipid architecture of the hetero-oligomeric cytochrome b6f complex. Structure. 2014 ;22(7):1008-15.

S Hasan S, Zakharov SD, Chauvet A, Stadnytskyi V, Savikhin S, Cramer WA. A map of dielectric heterogeneity in a membrane protein: the hetero-oligomeric cytochrome b6f complex. J Phys Chem B. 2014 ;118(24):6614-25.

S Hasan S, Rizvi A, Naseem I. Calcitriol-induced DNA damage: toward a molecular mechanism of selective cell death. IUBMB Life. 2013 ;65(9):787-92.

Kishor A, Tandukar B, Ly YV, Toth EA, Suarez Y, Brewer G, Wilson GM. Hsp70 is a novel posttranscriptional regulator of gene expression that binds and stabilizes selected mRNAs containing AU-rich elements. Mol Cell Biol. 2013 ;33(1):71-84.

S Hasan S, Stofleth JT, Yamashita E, Cramer WA. Lipid-induced conformational changes within the cytochrome b6f complex of oxygenic photosynthesis. Biochemistry. 2013 ;52(15):2649-54.

Cao X, Yap JL, M Newell-Rogers K, Peddaboina C, Jiang W, Papaconstantinou HT, Jupitor D, Rai A, Jung K-Y, Tubin RP, et al. The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak. Mol Cancer. 2013 ;12(1):42.

S Hasan S, Yamashita E, Baniulis D, Cramer WA. Quinone-dependent proton transfer pathways in the photosynthetic cytochrome b6f complex. Proc Natl Acad Sci U S A. 2013 ;110(11):4297-302.

Pazgier M, Ericksen B, Ling M, Toth EA, Shi J, Li X, Galliher-Beckley A, Lan L, Zou G, Zhan C, et al. Structural and functional analysis of the pro-domain of human cathelicidin, LL-37. Biochemistry. 2013 ;52(9):1547-58.

Sabit H, Mallajosyula SS, Mackerell AD, Swaan PW. Transmembrane domain II of the human bile acid transporter SLC10A2 coordinates sodium translocation. J Biol Chem. 2013 ;288(45):32394-404.

Huang J, Ofek GA, Laub L, Louder MK, Doria-Rose NA, Longo NS, Imamichi H, Bailer RT, Chakrabarti B, Sharma SK, et al. Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature. 2012 ;491(7424):406-12.

Chao KL, Tsai I-W, Chen C, Herzberg O. Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. PLoS One. 2012 ;7(7):e41912.

Wang X, Culver JN. DNA binding specificity of ATAF2, a NAC domain transcription factor targeted for degradation by Tobacco mosaic virus. BMC Plant Biol. 2012 ;12:157.

Maiti A, Noon MS, Mackerell AD, Pozharski E, Drohat AC. Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA. Proc Natl Acad Sci U S A. 2012 ;109(21):8091-6.

S Hasan S, Cramer WA. Lipid functions in cytochrome bc complexes: an odd evolutionary transition in a membrane protein structure. Philos Trans R Soc Lond B Biol Sci. 2012 ;367(1608):3406-11.

He Y, Chen Y, Alexander PA, Bryan PN, Orban J. Mutational tipping points for switching protein folds and functions. Structure. 2012 ;20(2):283-91.

Shi Z, Sellers J, Moult J. Protein stability and in vivo concentration of missense mutations in phenylalanine hydroxylase. Proteins. 2012 ;80(1):61-70.

González PM, Hussainzada N, Swaan PW, Mackerell AD, Polli JE. Putative irreversible inhibitors of the human sodium-dependent bile acid transporter (hASBT; SLC10A2) support the role of transmembrane domain 7 in substrate binding/translocation. Pharm Res. 2012 ;29(7):1821-31.

Yap JL, Cao X, Vanommeslaeghe K, Jung K-Y, Peddaboina C, Wilder PT, Nan A, Mackerell AD, W Smythe R, Fletcher S. Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors. Org Biomol Chem. 2012 ;10(15):2928-33.

He Y, Chen Y, Oganesyan N, Ruan B, O'Brochta DA, Bryan PN, Orban J. Solution NMR structure of a sheddase inhibitor prodomain from the malarial parasite Plasmodium falciparum. Proteins. 2012 ;80(12):2810-7.

McGowan S, Buckle AM, Mitchell MS, Hoopes JT, D Gallagher T, Heselpoth RD, Shen Y, Reboul CF, Law RHP, Fischetti VA, et al. X-ray crystal structure of the streptococcal specific phage lysin PlyC. Proc Natl Acad Sci U S A. 2012 ;109(31):12752-7.

Wang XXiang, Li Y, Yin Y, Mo M, Wang Q, Gao W, Wang L, Mariuzza RA. Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex. Proc Natl Acad Sci U S A. 2011 ;108(38):15960-5.