IBBR Publications

Found 12 results
Filters: Author is Heselpoth, Ryan D  [Clear All Filters]
2021
Broendum SS, Williams DE, Hayes BK, Kraus F, Fodor J, Clifton BE, Volbeda AGeert, Codee JDC, Riley BT, Drinkwater N, et al. High avidity drives the interaction between the streptococcal C1 phage endolysin, PlyC, with the cell surface carbohydrates of Group A Streptococcus. Mol Microbiol. 2021 .
2020
Greenfield J, Shang X, Luo H, Zhou Y, Linden SB, Heselpoth RD, Leiman PG, Nelson DC, Herzberg O. Structure and function of bacteriophage CBA120 ORF211 (TSP2), the determinant of phage specificity towards E. coli O157:H7. Sci Rep. 2020 ;10(1):15402.
2019
Greenfield J, Shang X, Luo H, Zhou Y, Heselpoth RD, Nelson DC, Herzberg O. Structure and tailspike glycosidase machinery of ORF212 from E. coli O157:H7 phage CBA120 (TSP3). Sci Rep. 2019 ;9(1):7349.
2016
Shen Y, Barros M, Vennemann T, D Gallagher T, Yin Y, Linden SB, Heselpoth RD, Spencer DJ, Donovan DM, Moult J, et al. A bacteriophage endolysin that eliminates intracellular streptococci. Elife. 2016 ;5.
Yang X, Lin Y-P, Heselpoth RD, Buyuktanir O, Qin J, Kung F, Nelson DC, Leong JM, Pal U. Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection. Cell Microbiol. 2016 ;18(1):97-110.
2015
Heselpoth RD, Yin Y, Moult J, Nelson DC. Increasing the stability of the bacteriophage endolysin PlyC using rationale-based FoldX computational modeling. Protein Eng Des Sel. 2015 ;28(4):85-92.
2014
Linden SB, Zhang H, Heselpoth RD, Shen Y, Schmelcher M, Eichenseher F, Nelson DC. Biochemical and biophysical characterization of PlyGRCS, a bacteriophage endolysin active against methicillin-resistant Staphylococcus aureus. Appl Microbiol Biotechnol. 2014 .
Swift SM, Hudgens JW, Heselpoth RD, Bales PM, Nelson DC. Characterization of AlgMsp, an alginate lyase from Microbulbifer sp. 6532A. PLoS One. 2014 ;9(11):e112939.
Chen C, Bales P, Greenfield J, Heselpoth RD, Nelson DC, Herzberg O. Crystal Structure of ORF210 from E. coli O157:H1 Phage CBA120 (TSP1), a Putative Tailspike Protein. PLoS One. 2014 ;9(3):e93156.
Heselpoth RD, Owens JM, Nelson DC. Quantitative analysis of the thermal stability of the gamma phage endolysin PlyG: A biophysical and kinetic approach to assaying therapeutic potential. Virology. 2014 .
2012
Heselpoth RD, Nelson DC. A new screening method for the directed evolution of thermostable bacteriolytic enzymes. J Vis Exp. 2012 ;(69).
McGowan S, Buckle AM, Mitchell MS, Hoopes JT, D Gallagher T, Heselpoth RD, Shen Y, Reboul CF, Law RHP, Fischetti VA, et al. X-ray crystal structure of the streptococcal specific phage lysin PlyC. Proc Natl Acad Sci U S A. 2012 ;109(31):12752-7.