Publications

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Bacterial secretions of nonpathogenic Escherichia coli elicit inflammatory pathways: a closer investigation of interkingdom signaling.
Zargar A, Quan DN, Carter KK, Guo M, Sintim HO, Payne GF, Bentley WE. 2015. Bacterial secretions of nonpathogenic Escherichia coli elicit inflammatory pathways: a closer investigation of interkingdom signaling. mBio 6(2): e00025. DOI: 10.1128/mBio.00025-15
Peptidoglycan recognition protein-peptidoglycan complexes increase monocyte/macrophage activation and enhance the inflammatory response.
De Marzi MC, Todone M, Ganem MB, Wang Q, Mariuzza RA, Fernández MM, Malchiodi EL. 2015. Peptidoglycan recognition protein-peptidoglycan complexes increase monocyte/macrophage activation and enhance the inflammatory response. Immunology 145(3): 429-42. DOI: 10.1111/imm.12460
Increasing the stability of the bacteriophage endolysin PlyC using rationale-based FoldX computational modeling.
Heselpoth RD, Yin Y, Moult J, Nelson DC. 2015. Increasing the stability of the bacteriophage endolysin PlyC using rationale-based FoldX computational modeling. Protein engineering, design & selection : PEDS 28(4): 85-92. DOI: 10.1093/protein/gzv004
Structural basis for penetration of the glycan shield of hepatitis C virus E2 glycoprotein by a broadly neutralizing human antibody.
Li Y, Pierce BG, Wang Q, Keck ZY, Fuerst TR, Foung SK, Mariuzza RA. 2015. Structural basis for penetration of the glycan shield of hepatitis C virus E2 glycoprotein by a broadly neutralizing human antibody. The Journal of biological chemistry 290(16): 10117-25. DOI: 10.1074/jbc.M115.643528
Mapping monoclonal antibody structure by 2D 13C NMR at natural abundance.
Arbogast LW, Brinson RG, Marino JP. 2015. Mapping monoclonal antibody structure by 2D 13C NMR at natural abundance. Analytical chemistry 87(7): 3556-61. DOI: 10.1021/ac504804m
Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf.
Samadani R, Zhang J, Brophy A, Oashi T, Priyakumar UD, Raman EP, St John FJ, Jung KY, Fletcher S, Pozharski E, et al. 2015. Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf. The Biochemical journal 467(3): 425-38. DOI: 10.1042/BJ20131571
Mapping functional group free energy patterns at protein occluded sites: nuclear receptors and G-protein coupled receptors.
Lakkaraju SK, Yu W, Raman EP, Hershfeld AV, Fang L, Deshpande DA, MacKerell AD. 2015. Mapping functional group free energy patterns at protein occluded sites: nuclear receptors and G-protein coupled receptors. Journal of chemical information and modeling 55(3): 700-8. DOI: 10.1021/ci500729k
Distal modulation of bacterial cell-cell signalling in a synthetic ecosystem using partitioned microfluidics.
Luo X, Tsao CY, Wu HC, Quan DN, Payne GF, Rubloff GW, Bentley WE. 2015. Distal modulation of bacterial cell-cell signalling in a synthetic ecosystem using partitioned microfluidics. Lab on a chip 15(8): 1842-51. DOI: 10.1039/c5lc00107b
Bone marrow plasma cells are a primary source of serum HIV-1-specific antibodies in chronically infected individuals.
Montezuma-Rusca JM, Moir S, Kardava L, Buckner CM, Louie A, Kim LJ, Santich BH, Wang W, Fankuchen OR, Diaz G, et al. 2015. Bone marrow plasma cells are a primary source of serum HIV-1-specific antibodies in chronically infected individuals. Journal of immunology (Baltimore, Md. : 1950) 194(6): 2561-8. DOI: 10.4049/jimmunol.1402424
Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosis.
Ravala SK, Singh S, Yadav GS, Kumar S, Karthikeyan S, Chakraborti PK. 2015. Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase from Mycobacterium tuberculosis. The FEBS journal 282(8): 1419-31. DOI: 10.1111/febs.13230
Polyionic vaccine adjuvants: another look at aluminum salts and polyelectrolytes.
Powell BS, Andrianov AK, Fusco PC. 2015. Polyionic vaccine adjuvants: another look at aluminum salts and polyelectrolytes. Clinical and experimental vaccine research 4(1): 23-45. DOI: 10.7774/cevr.2015.4.1.23
Novel C-4 heteroaryl 13-cis-retinamide Mnk/AR degrading agents inhibit cell proliferation and migration and induce apoptosis in human breast and prostate cancer cells and suppress growth of MDA-MB-231 human breast and CWR22Rv1 human prostate tumor xenografts in mice.
Mbatia HW, Ramalingam S, Ramamurthy VP, Martin MS, Kwegyir-Afful AK, Njar VC. 2015. Novel C-4 heteroaryl 13-cis-retinamide Mnk/AR degrading agents inhibit cell proliferation and migration and induce apoptosis in human breast and prostate cancer cells and suppress growth of MDA-MB-231 human breast and CWR22Rv1 human prostate tumor xenografts in mice. Journal of medicinal chemistry 58(4): 1900-14. DOI: 10.1021/jm501792c
Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection.
Schmelcher M, Shen Y, Nelson DC, Eugster MR, Eichenseher F, Hanke DC, Loessner MJ, Dong S, Pritchard DG, Lee JC, et al. 2015. Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection. The Journal of antimicrobial chemotherapy 70(5): 1453-65. DOI: 10.1093/jac/dku552
Molecular modeling of nucleic Acid structure: electrostatics and solvation.
Bergonzo C, Galindo-Murillo R, Cheatham TE. 2014. Molecular modeling of nucleic Acid structure: electrostatics and solvation. Current protocols in nucleic acid chemistry 55: 7.9.1-27. DOI: 10.1002/0471142700.nc0709s55
HIV-1 fitness cost associated with escape from the VRC01 class of CD4 binding site neutralizing antibodies.
Lynch RM, Wong P, Tran L, O'Dell S, Nason MC, Li Y, Wu X, Mascola JR. 2015. HIV-1 fitness cost associated with escape from the VRC01 class of CD4 binding site neutralizing antibodies. Journal of virology 89(8): 4201-13. DOI: 10.1128/JVI.03608-14