Publications

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Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer.
Mohanty A, Nam A, Srivastava S, Jones J, Lomenick B, Singhal SS, Guo L, Cho H, Li A, Behal A, et al. 2023. Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer. Science advances 9(41): eade3816. DOI: 10.1126/sciadv.ade3816
Lysosomal Therapies and Drug Delivery Strategies: An Overview.
Muro S. 2023. Lysosomal Therapies and Drug Delivery Strategies: An Overview. Advanced drug delivery reviews : 115112. DOI: 10.1016/j.addr.2023.115112
Zika virus NS4B protein targets TANK-binding kinase 1 and inhibits type I interferon production.
Sarratea MB, Alberti AS, Redolfi DM, Truant SN, Iannantuono Lopez LV, Bivona AE, Mariuzza RA, Fernández MM, Malchiodi EL. 2023. Zika virus NS4B protein targets TANK-binding kinase 1 and inhibits type I interferon production. Biochimica et biophysica acta. General subjects : 130483. DOI: 10.1016/j.bbagen.2023.130483
Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation.
Lee YS, Cheng IT, Raquel GR, Weber DJ, Scalea JR. 2023. Initial exploration of a novel fusion protein, IL-4/IL-34/IL-10, which promotes cardiac allograft survival mice through alloregulation. Innate immunity 29(7): 150-158. DOI: 10.1177/17534259231186239
Mutation and Selection Induce Correlations between Selection Coefficients and Mutation Rates.
Gitschlag BL, Cano AV, Payne JL, McCandlish DM, Stoltzfus A. 2023. Mutation and Selection Induce Correlations between Selection Coefficients and Mutation Rates. The American naturalist 202(4): 534-557. DOI: 10.1086/726014
Immunogenic epitope scanning in bacteriolytic enzymes Pal and Cpl-1 and engineering Pal to escape antibody responses.
Harhala MA, Gembara K, Rybicka I, Kaźmierczak ZM, Miernikiewicz P, Majewska JM, Budziar W, Nasulewicz-Goldeman A, Nelson DC, Owczarek B, et al. 2023. Immunogenic epitope scanning in bacteriolytic enzymes Pal and Cpl-1 and engineering Pal to escape antibody responses. Frontiers in immunology 14: 1075774. DOI: 10.3389/fimmu.2023.1075774
VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2.
Thankan RS, Thomas E, Purushottamachar P, Weber DJ, Ramamurthy VP, Huang W, Kane MA, Njar VCO. 2023. VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins <i>in vitro</i> and <i>in vivo</i> by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2. Frontiers in oncology 13: 1240996. DOI: 10.3389/fonc.2023.1240996
Role of the Lactide:Glycolide Ratio in PLGA Nanoparticle Stability and Release under Lysosomal Conditions for Enzyme Replacement Therapy of Lysosomal Storage Disorders.
Del Moral M, Loeck M, Muntimadugu E, Vives G, Pham V, Pfeifer P, Battaglia G, Muro S. 2023. Role of the Lactide:Glycolide Ratio in PLGA Nanoparticle Stability and Release under Lysosomal Conditions for Enzyme Replacement Therapy of Lysosomal Storage Disorders. Journal of functional biomaterials 14(9): . DOI: 10.3390/jfb14090440
Role of Domain-Domain Interactions on the Self-Association and Physical Stability of Monoclonal Antibodies: Effect of pH and Salt.
Xu AY, Blanco MA, Castellanos MM, Meuse CW, Mattison K, Karageorgos I, Hatch HW, Shen VK, Curtis JE. 2023. Role of Domain-Domain Interactions on the Self-Association and Physical Stability of Monoclonal Antibodies: Effect of pH and Salt. The journal of physical chemistry. B : . DOI: 10.1021/acs.jpcb.3c03928
Neuroimaging in insomnia: Review and reconsiderations.
Aquino G, Schiel JE. 2023. Neuroimaging in insomnia: Review and reconsiderations. Journal of sleep research : e14030. DOI: 10.1111/jsr.14030
Screening in serum-derived medium reveals differential response to compounds targeting metabolism.
Abbott KL, Ali A, Casalena D, Do BT, Ferreira R, Cheah JH, Soule CK, Deik A, Kunchok T, Schmidt DR, et al. 2023. Screening in serum-derived medium reveals differential response to compounds targeting metabolism. Cell chemical biology : . DOI: 10.1016/j.chembiol.2023.08.007
Combining SILCS and Artificial Intelligence for High-Throughput Prediction of the Passive Permeability of Drug Molecules.
Pandey P, MacKerell AD. 2023. Combining SILCS and Artificial Intelligence for High-Throughput Prediction of the Passive Permeability of Drug Molecules. Journal of chemical information and modeling : . DOI: 10.1021/acs.jcim.3c00514
Endosomal activation of the Clostridioides difficile binary toxin is Ca 2+ -dependent.
Abeyawardhane DL, Adipietro KA, Godoy-Ruiz R, Varney KM, Sevdalis SE, Nawaz IF, Spittel AX, Rustandi RR, Silin VI, des Georges A, et al. 2023. Endosomal activation of the <i>Clostridioides difficile</i> binary toxin is Ca 2+ -dependent. bioRxiv : the preprint server for biology : . DOI: 10.1101/2023.08.18.553786
Strategies for rapid production of crystallization quality coatomer WD40 domains.
Dey D, Hasan SS. 2023. Strategies for rapid production of crystallization quality coatomer WD40 domains. Protein expression and purification : 106358. DOI: 10.1016/j.pep.2023.106358
CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker.
Mishra AK, Shahid S, Karade SS, Agnihotri P, Kolesnikov A, Hasan SS, Mariuzza RA. 2023. CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker. Structure (London, England : 1993) : . DOI: 10.1016/j.str.2023.07.013