Publications

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Structural metamorphism and polymorphism in proteins on the brink of thermodynamic stability.
Kulkarni P, Solomon TL, He Y, Chen Y, Bryan PN, Orban J. 2018. Structural metamorphism and polymorphism in proteins on the brink of thermodynamic stability. Protein science : a publication of the Protein Society 27(9): 1557-1567. DOI: 10.1002/pro.3458
Peptide-MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites.
Rangarajan S, He Y, Chen Y, Kerzic MC, Ma B, Gowthaman R, Pierce BG, Nussinov R, Mariuzza RA, Orban J. 2018. Peptide-MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites. The Journal of biological chemistry 293(41): 15991-16005. DOI: 10.1074/jbc.RA118.003832
IgG3 regulates tissue-like memory B cells in HIV-infected individuals.
Kardava L, Sohn H, Youn C, Austin JW, Wang W, Buckner CM, Justement JS, Melson VA, Roth GE, Hand MA, et al. 2018. IgG3 regulates tissue-like memory B cells in HIV-infected individuals. Nature immunology 19(9): 1001-1012. DOI: 10.1038/s41590-018-0180-5
Loss of S100A1 expression leads to Ca2+ release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1.
Hernández-Ochoa EO, Melville Z, Vanegas C, Varney KM, Wilder PT, Melzer W, Weber DJ, Schneider MF. 2018. Loss of S100A1 expression leads to Ca2+ release potentiation in mutant mice with disrupted CaM and S100A1 binding to CaMBD2 of RyR1. Physiological reports 6(15): e13822. DOI: 10.14814/phy2.13822
Proteomic Toolbox To Standardize the Separation of Extracellular Vesicles and Lipoprotein Particles.
Wang T, Turko IV. 2018. Proteomic Toolbox To Standardize the Separation of Extracellular Vesicles and Lipoprotein Particles. Journal of proteome research 17(9): 3104-3113. DOI: 10.1021/acs.jproteome.8b00225
Platform development for expression and purification of stable isotope labeled monoclonal antibodies in Escherichia coli.
Reddy PT, Brinson RG, Hoopes JT, McClung C, Ke N, Kashi L, Berkmen M, Kelman Z. 2018. Platform development for expression and purification of stable isotope labeled monoclonal antibodies in Escherichia coli. mAbs 10(7): 992-1002. DOI: 10.1080/19420862.2018.1496879
Designed peptides that assemble into cross-α amyloid-like structures.
Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, Shu X, Liu L, DeGrado WF. 2018. Designed peptides that assemble into cross-α amyloid-like structures. Nature chemical biology 14(9): 870-875. DOI: 10.1038/s41589-018-0105-5
Development of Cell-Based Sentinels for Nitric Oxide: Ensuring Marker Expression and Unimodality.
McKay R, Hauk P, Quan D, Bentley WE. 2018. Development of Cell-Based Sentinels for Nitric Oxide: Ensuring Marker Expression and Unimodality. ACS synthetic biology 7(7): 1694-1701. DOI: 10.1021/acssynbio.8b00146
Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design.
Cheng H, Linhares BM, Yu W, Cardenas MG, Ai Y, Jiang W, Winkler A, Cohen S, Melnick A, MacKerell A, et al. 2018. Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design. Journal of medicinal chemistry 61(17): 7573-7588. DOI: 10.1021/acs.jmedchem.8b00040
Heterologous recombinant expression of non-originator NISTmAb.
Kashi L, Yandrofski K, Preston RJ, Arbogast LW, Giddens JP, Marino JP, Schiel JE, Kelman Z. 2022. Heterologous recombinant expression of non-originator NISTmAb. mAbs 10(6): 922-933. DOI: 10.1080/19420862.2018.1486355
Hydrolytically Degradable PEGylated Polyelectrolyte Nanocomplexes for Protein Delivery.
Andrianov AK, Marin A, Martinez AP, Weidman JL, Fuerst TR. 2018. Hydrolytically Degradable PEGylated Polyelectrolyte Nanocomplexes for Protein Delivery. Biomacromolecules 19(8): 3467-3478. DOI: 10.1021/acs.biomac.8b00785
Radical Scavenging Activities of Biomimetic Catechol-Chitosan Films.
Cao C, Kim E, Liu Y, Kang M, Li J, Yin JJ, Liu H, Qu X, Liu C, Bentley WE, et al. 2018. Radical Scavenging Activities of Biomimetic Catechol-Chitosan Films. Biomacromolecules 19(8): 3502-3514. DOI: 10.1021/acs.biomac.8b00809
Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target.
Salgia R, Jolly MK, Dorff T, Lau C, Weninger K, Orban J, Kulkarni P. 2018. Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target. Journal of clinical medicine 7(6): . DOI: 10.3390/jcm7060156
Arabidopsis phospholipase Dα1 and Dδ oppositely modulate EDS1- and SA-independent basal resistance against adapted powdery mildew.
Zhang Q, Berkey R, Blakeslee JJ, Lin J, Ma X, King H, Liddle A, Guo L, Munnik T, Wang X, et al. 2018. Arabidopsis phospholipase Dα1 and Dδ oppositely modulate EDS1- and SA-independent basal resistance against adapted powdery mildew. Journal of experimental botany 69(15): 3675-3688. DOI: 10.1093/jxb/ery146
Archaeal DNA replication and repair: new genetic, biophysical and molecular tools for discovering and characterizing enzymes, pathways and mechanisms.
Zatopek KM, Gardner AF, Kelman Z. 2018. Archaeal DNA replication and repair: new genetic, biophysical and molecular tools for discovering and characterizing enzymes, pathways and mechanisms. FEMS microbiology reviews 42(4): 477-488. DOI: 10.1093/femsre/fuy017