The Effect of Ionic Strength on the Mechanical, Structural and Transport Properties of Peptide Hydrogels.

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TitleThe Effect of Ionic Strength on the Mechanical, Structural and Transport Properties of Peptide Hydrogels.
Publication TypeJournal Article
Year of Publication2012
AuthorsFeng, Y, Taraban, M, Y Yu, B
JournalSoft Matter
Volume8
Issue46
Pagination11723-11731
Date Published2012 Jan 01
ISSN1744-6848
Abstract

It is found that the elastic modulus of a peptide hydrogel increases linearly with the logarithm of its ionic strength. This result indicates that the elastic modulus of this class of hydrogels can be tuned by the ionic strength in a highly predictable manner. Small-angle X-ray scattering studies reveal that higher ionic strength leads to thinner but more rigid peptide fibers that are packed more densely. The self-diffusion coefficient of small molecules inside the hydrogel decrease linearly with its ionic strength, but this decrease is mainly a salt effect rather than diffusion barriers imposed by the hydrogel matrix.

DOI10.1039/C2SM26572A
Alternate JournalSoft Matter
PubMed ID23185209
PubMed Central IDPMC3505094
Grant ListR01 EB004416 / EB / NIBIB NIH HHS / United States