Split of chiral degeneracy in mechanical and structural properties of oligopeptide-polysaccharide biomaterials.

Printer-friendly versionPrinter-friendly versionPDF versionPDF version
TitleSplit of chiral degeneracy in mechanical and structural properties of oligopeptide-polysaccharide biomaterials.
Publication TypeJournal Article
Year of Publication2013
AuthorsTaraban, MB, Hyland, LL, Y Yu, B
JournalBiomacromolecules
Volume14
Issue9
Pagination3192-201
Date Published2013 Sep 09
ISSN1526-4602
KeywordsBiocompatible Materials, Cellulose, Chondroitin Sulfates, Cyclodextrins, Elastic Modulus, Glycogen, Humans, Hydrogels, Materials Testing, Models, Chemical, Models, Molecular, Oligopeptides, Scattering, Small Angle, Stereoisomerism, X-Ray Diffraction
Abstract

Enantiomeric biomaterials which are mirror images of each other are characterized by chiral degeneracy--identical structural characteristics and bulk material properties. The addition of another chiral component, D-polysaccharide, has been shown to split such degeneracy and result in two distinct biomaterials. Dynamic oscillatory rheometry and small-angle X-ray scattering demonstrate that the natural biochirality combination of L-peptides and D-polysaccharides assembles faster, has higher elastic moduli (G'), and is structurally more beneficial as opposed to the alternative D-peptide and D-polysaccharide combination. Chemical modifications of the OH-groups in α-D-glucose units in D-polysaccharides weaken such splitting of chiral degeneracy. These findings form a basis to design novel biomaterials and provide additional insight on why proteins and polysaccharides have oppoiste chirality in the biological world.

DOI10.1021/bm4008309
Alternate JournalBiomacromolecules
PubMed ID23879188
PubMed Central IDPMC3869456
Grant ListR01 EB004416 / EB / NIBIB NIH HHS / United States
EB004416 / EB / NIBIB NIH HHS / United States