Water proton NMR detection of amide hydrolysis and diglycine dimerization.

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TitleWater proton NMR detection of amide hydrolysis and diglycine dimerization.
Publication TypeJournal Article
Year of Publication2018
AuthorsBriggs, KT, Taraban, MB, Y Yu, B
JournalChem Commun (Camb)
Volume54
Issue51
Pagination7003-7006
Date Published2018 Jun 21
ISSN1364-548X
Abstract

The transverse relaxation rate of water protons R2(1H2O) is found to be sensitive to amide hydrolysis and diglycine dimerization. The results demonstrate the feasibility of using R2(1H2O) as a diagnostic tool to detect chemical changes in aqueous solutions. Potential applications include drug product formulation and inspection.

DOI10.1039/c8cc03935f
Alternate JournalChem. Commun. (Camb.)
PubMed ID29850691