Alterations in Cellular Processes Involving Vesicular Trafficking and Implications in Drug Delivery.

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TitleAlterations in Cellular Processes Involving Vesicular Trafficking and Implications in Drug Delivery.
Publication TypeJournal Article
Year of Publication2018
AuthorsMuro, S
JournalBiomimetics (Basel)
Volume3
Issue3
Date Published2018 Jul 24
ISSN2313-7673
Abstract

Endocytosis and vesicular trafficking are cellular processes that regulate numerous functions required to sustain life. From a translational perspective, they offer avenues to improve the access of therapeutic drugs across cellular barriers that separate body compartments and into diseased cells. However, the fact that many factors have the potential to alter these routes, impacting our ability to effectively exploit them, is often overlooked. Altered vesicular transport may arise from the molecular defects underlying the pathological syndrome which we aim to treat, the activity of the drugs being used, or side effects derived from the drug carriers employed. In addition, most cellular models currently available do not properly reflect key physiological parameters of the biological environment in the body, hindering translational progress. This article offers a critical overview of these topics, discussing current achievements, limitations and future perspectives on the use of vesicular transport for drug delivery applications.

DOI10.3390/biomimetics3030019
Alternate JournalBiomimetics (Basel)
PubMed ID31105241
PubMed Central IDPMC6352689
Grant List2R01-HL98416 / / National Institutes of Health /
sponsored research agreement 17092850 / / Genisphere LLC /
SEV-2014-0425 / / Spanish Ministry of Economy and Competitiveness MINECO/FEDER /
CERCA Program / / Generalitat de Catalunya /