How Natural Killer Cell Receptors Stick to Cell-Cell Adhesion Proteins.

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TitleHow Natural Killer Cell Receptors Stick to Cell-Cell Adhesion Proteins.
Publication TypeJournal Article
Year of Publication2019
AuthorsKarade, SS, Mariuzza, RA
JournalStructure
Volume27
Issue2
Pagination209-210
Date Published2019 Feb 05
ISSN1878-4186
Abstract

The cytolytic activity of NK cells is regulated by activating and inhibitory receptors, including ones that recognize cell-cell adhesion molecules. In this issue of Structure, Deuss et al. (2019) report the structure of nectin-like protein-5 bound to the NK inhibitory receptor CD96, a promising new target for cancer immunotherapy.

DOI10.1016/j.str.2019.01.007
Alternate JournalStructure
PubMed ID30726753