Neutron scattering in the biological sciences: progress and prospects.

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TitleNeutron scattering in the biological sciences: progress and prospects.
Publication TypeJournal Article
Year of Publication2018
AuthorsAshkar, R, Bilheux, HZ, Bordallo, H, Briber, R, Callaway, DJE, Cheng, X, Chu, XQiang, Curtis, JE, Dadmun, M, Fenimore, P, Fushman, D, Gabel, F, Gupta, K, Herberle, F, Heinrich, F, Hong, L, Katsaras, J, Kelman, Z, Kharlampieva, E, Kneller, GR, Kovalevsky, A, Krueger, S, Langan, P, Lieberman, R, Liu, Y, Lösche, M, Lyman, E, Mao, Y, Marino, JP, Mattos, C, Meilleur, F, Moody, P, Nickels, JD, O'Dell, WB, O'Neill, H, Perez-Salas, U, Peters, J, Petridis, L, Sokolov, AP, Stanley, C, Wagner, N, Weinrich, M, Weiss, K, Wymore, T, Zhang, Y, Smith, JC
JournalActa Crystallogr D Struct Biol
Volume74
IssuePt 12
Pagination1129-1168
Date Published2018 Dec 01
ISSN2059-7983
Abstract

The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple length and time scales. Pursuant to a National Science Foundation-funded workshop in February 2018, recent developments in this field are reviewed here, as well as future prospects that can be expected given recent advances in sources, instrumentation and computational power and methods. Crystallography, solution scattering, dynamics, membranes, labeling and imaging are examined. For the extraction of maximum information, the incorporation of judicious specific deuterium labeling, the integration of several types of experiment, and interpretation using high-performance computer simulation models are often found to be particularly powerful.

DOI10.1107/S2059798318017503
Alternate JournalActa Crystallogr D Struct Biol
PubMed ID30605130