

Title | Structural biology of Zika virus and other flaviviruses. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | S Hasan, S, Sevvana, M, Kuhn, RJ, Rossmann, MG |
Journal | Nat Struct Mol Biol |
Volume | 25 |
Issue | 1 |
Pagination | 13-20 |
Date Published | 2018 01 |
ISSN | 1545-9985 |
Keywords | Animals, Antibodies, Neutralizing, Antibodies, Viral, Cryoelectron Microscopy, Dengue Virus, Encephalitis Virus, Japanese, Female, Guillain-Barre Syndrome, Humans, Male, Mice, Microcephaly, Models, Biological, Pregnancy, Protein Conformation, United States, Virus Assembly, Virus Internalization, West Nile virus, Zika Virus, Zika Virus Infection |
Abstract | Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked to fetal microcephaly and the paralytic Guillain-Barré syndrome. This review provides a comparative structural analysis of the assembly, maturation and host-cell entry of ZIKV with other flaviviruses, especially DENV. We also discuss the mechanisms of neutralization by antibodies. |
DOI | 10.1038/s41594-017-0010-8 |
Alternate Journal | Nat. Struct. Mol. Biol. |
PubMed ID | 29323278 |