Iodobenzene-Catalyzed Synthesis of Phenanthridinones via Oxidative C-H Amidation.

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TitleIodobenzene-Catalyzed Synthesis of Phenanthridinones via Oxidative C-H Amidation.
Publication TypeJournal Article
Year of Publication2017
AuthorsLiang, D, Yu, W, Nguyen, N, Deschamps, JR, Imler, GH, Li, Y, Mackerell, AD, Jiang, C, Xue, F
JournalJ Org Chem
Volume82
Issue7
Pagination3589-3596
Date Published2017 Apr 07
ISSN1520-6904
Abstract

We report a novel synthesis of phenanthridinones from N-methoxybenzamides using an oxidative C-H amidation reaction at room temperature in open air with modest to excellent yields. This method demonstrated unprecedented substrate scope. In particular, it solved the long-standing challenge in the synthesis of phenanthridinones with sterically demanding substitutions.

DOI10.1021/acs.joc.7b00106
Alternate JournalJ. Org. Chem.
PubMed ID28245353