

Title | Iodobenzene-Catalyzed Synthesis of Phenanthridinones via Oxidative C-H Amidation. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Liang, D, Yu, W, Nguyen, N, Deschamps, JR, Imler, GH, Li, Y, Mackerell, AD, Jiang, C, Xue, F |
Journal | J Org Chem |
Volume | 82 |
Issue | 7 |
Pagination | 3589-3596 |
Date Published | 2017 Apr 07 |
ISSN | 1520-6904 |
Abstract | We report a novel synthesis of phenanthridinones from N-methoxybenzamides using an oxidative C-H amidation reaction at room temperature in open air with modest to excellent yields. This method demonstrated unprecedented substrate scope. In particular, it solved the long-standing challenge in the synthesis of phenanthridinones with sterically demanding substitutions. |
DOI | 10.1021/acs.joc.7b00106 |
Alternate Journal | J. Org. Chem. |
PubMed ID | 28245353 |