Molecular processes in an electrochemical clozapine sensor.

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TitleMolecular processes in an electrochemical clozapine sensor.
Publication TypeJournal Article
Year of Publication2017
AuthorsWinkler, TE, Lederer, SL, Kim, E, Ben-Yoav, H, Kelly, DL, Payne, GF, Ghodssi, R
Date Published2017 May 01

Selectivity presents a crucial challenge in direct electrochemical sensing. One example is schizophrenia treatment monitoring of the redox-active antipsychotic clozapine. To accurately assess efficacy, differentiation from its metabolite norclozapine-similar in structure and redox potential-is critical. Here, the authors leverage biomaterials integration to study, and effect changes in, diffusion and electron transfer kinetics of these compounds. Specifically, the authors employ a catechol-modified chitosan film, which the authors have previously presented as the first electrochemical detection mechanism capable of quantifying clozapine directly in clinical serum. A key finding in our present work is differing dynamics between clozapine and norclozapine once the authors interface the electrodes with chitosan-based biomaterial films. These additional dimensions of redox information can thus enable selective sensing of largely analogous small molecules.

Alternate JournalBiointerphases
PubMed ID28460529