|Title||MHC class I recognition by Ly49 natural killer cell receptors.|
|Publication Type||Journal Article|
|Year of Publication||2002|
|Authors||Natarajan, K, Dimasi, N, Wang, J, Margulies, DH, Mariuzza, RA|
|Date Published||2002 May|
|Keywords||Animals, Antigens, Ly, Histocompatibility Antigens Class I, Humans, Killer Cells, Natural, Lectins, C-Type, Membrane Glycoproteins, Mice, Models, Molecular, NK Cell Lectin-Like Receptor Subfamily A, Protein Structure, Tertiary, Receptors, Immunologic, Receptors, NK Cell Lectin-Like|
Natural killer (NK) cell function is regulated by NK receptors that bind either classical MHC class I (MHC-I) molecules or their structural relatives (MICA, RAE-1 and H-60). Two distinct families of NK receptors have been identified: the C-type lectin-like family (Ly49, NKG2D and CD94/NKG2) and the immunoglobulin-like family (KIRs and LIRs). Here, we describe the crystal structure of the C-type lectin-like NK receptor (Ly49A), bound to its MHC-I ligand (H-2D(d)). We also discuss results from recent mutagenesis studies of the Ly49A/H-2D(d) interaction in the context of the complex structure.
|Alternate Journal||Mol. Immunol.|