Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide.

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TitleGlobal transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide.
Publication TypeJournal Article
Year of Publication2006
AuthorsChang, W, Small, DA, Toghrol, F, Bentley, WE
JournalJ Bacteriol
Volume188
Issue4
Pagination1648-59
Date Published2006 Feb
ISSN0021-9193
KeywordsGene Expression Profiling, Gene Expression Regulation, Bacterial, Genes, Bacterial, Hydrogen Peroxide, Oligonucleotide Array Sequence Analysis, Polymerase Chain Reaction, RNA, Bacterial, RNA, Messenger, Staphylococcus aureus, Time Factors, Transcription, Genetic
Abstract

Staphylococcus aureus responds with protective strategies against phagocyte-derived reactive oxidants to infect humans. Herein, we report the transcriptome analysis of the cellular response of S. aureus to hydrogen peroxide-induced oxidative stress. The data indicate that the oxidative response includes the induction of genes involved in virulence, DNA repair, and notably, anaerobic metabolism.

DOI10.1128/JB.188.4.1648-1659.2006
Alternate JournalJ. Bacteriol.
PubMed ID16452450
PubMed Central IDPMC1367260