Critical assessment of methods of protein structure prediction-Round VII.

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TitleCritical assessment of methods of protein structure prediction-Round VII.
Publication TypeJournal Article
Year of Publication2007
AuthorsMoult, J, Fidelis, K, Kryshtafovych, A, Rost, B, Hubbard, T, Tramontano, A
JournalProteins
Volume69 Suppl 8
Pagination3-9
Date Published2007
ISSN1097-0134
KeywordsAlgorithms, Computational Biology, Databases, Protein, Evaluation Studies as Topic, Humans, Models, Molecular, Models, Statistical, Protein Conformation, Proteins
Abstract

This paper is an introduction to the supplemental issue of the journal PROTEINS, dedicated to the seventh CASP experiment to assess the state of the art in protein structure prediction. The paper describes the conduct of the experiment, the categories of prediction included, and outlines the evaluation and assessment procedures. Highlights are improvements in model accuracy relative to that obtainable from knowledge of a single best template structure; convergence of the accuracy of models produced by automatic servers toward that produced by human modeling teams; the emergence of methods for predicting the quality of models; and rapidly increasing practical applications of the methods.

DOI10.1002/prot.21767
Alternate JournalProteins
PubMed ID17918729
PubMed Central IDPMC2653632
Grant List077198 / / Wellcome Trust / United Kingdom
GM072354 / GM / NIGMS NIH HHS / United States
LM07085 / LM / NLM NIH HHS / United States