CASP8 results in context of previous experiments.

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TitleCASP8 results in context of previous experiments.
Publication TypeJournal Article
Year of Publication2009
AuthorsKryshtafovych, A, Fidelis, K, Moult, J
JournalProteins
Volume77 Suppl 9
Pagination217-28
Date Published2009
ISSN1097-0134
KeywordsComputational Biology, Models, Molecular, Protein Conformation, Protein Structure, Tertiary, Proteins, Sequence Alignment, Sequence Analysis, Protein
Abstract

The quality of structure models submitted to CASP8 is analyzed in the context of previous CASPs. To compare models from the latest experiment with their predecessors, we use the approaches consistent with the previous articles in this series. Using the basic evaluation measures accepted in CASP, there were no noticeable advances in the quality of the methods in any of the target difficulty categories. At the same time, there were three positive developments: (1) for set of the best models on each target, CASP8 registered the highest number of cases from all CASPs where alignment accuracy exceeded the maximum possible from the best template; (2) modeling accuracy of regions not present in the best template has improved; and (3) the loss in modeling quality from selection of nonoptimal models as the best ones submitted on the target has decreased.

DOI10.1002/prot.22562
Alternate JournalProteins
PubMed ID19722266
Grant ListLM07085 / LM / NLM NIH HHS / United States
P41 LM007085-10S1 / LM / NLM NIH HHS / United States
P41 LM007085-12 / LM / NLM NIH HHS / United States