Evaluation of template-based models in CASP8 with standard measures.

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TitleEvaluation of template-based models in CASP8 with standard measures.
Publication TypeJournal Article
Year of Publication2009
AuthorsCozzetto, D, Kryshtafovych, A, Fidelis, K, Moult, J, Rost, B, Tramontano, A
JournalProteins
Volume77 Suppl 9
Pagination18-28
Date Published2009
ISSN1097-0134
KeywordsAnimals, Computational Biology, Humans, Models, Molecular, Protein Conformation, Proteins, Sequence Analysis, Protein
Abstract

The strategy for evaluating template-based models submitted to CASP has continuously evolved from CASP1 to CASP5, leading to a standard procedure that has been used in all subsequent editions. The established approach includes methods for calculating the quality of each individual model, for assigning scores based on the distribution of the results for each target and for computing the statistical significance of the differences in scores between prediction methods. These data are made available to the assessor of the template-based modeling category, who uses them as a starting point for further evaluations and analyses. This article describes the detailed workflow of the procedure, provides justifications for a number of choices that are customarily made for CASP data evaluation, and reports the results of the analysis of template-based predictions at CASP8.

DOI10.1002/prot.22561
Alternate JournalProteins
PubMed ID19731382
Grant ListLM-07085 / LM / NLM NIH HHS / United States
P41 LM007085-10 / LM / NLM NIH HHS / United States
P41 LM007085-12 / LM / NLM NIH HHS / United States