Assessment of protein disorder region predictions in CASP10.

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TitleAssessment of protein disorder region predictions in CASP10.
Publication TypeJournal Article
Year of Publication2013
AuthorsMonastyrskyy, B, Kryshtafovych, A, Moult, J, Tramontano, A, Fidelis, K
JournalProteins
Date Published2013 Aug 14
ISSN1097-0134
Abstract

The paper presents the assessment of disorder region predictions submitted to CASP10. The evaluation is based on the three measures tested in previous CASPs: (i) balanced accuracy, (ii) the Matthews correlation coefficient for the binary predictions and (iii) the area under the curve in ROC analysis of predictions using probability annotation. We also performed new analyses such as comparison of the submitted predictions with those obtained with a naïve disorder prediction method and with predictions from the disorder prediction databases D2P2 and MobiDB. On average, the methods participating in CASP10 demonstrated slightly better performance than those in CASP9. © Proteins 2013;. © 2013 Wiley Periodicals, Inc.

DOI10.1002/prot.24391
Alternate JournalProteins
PubMed ID23946100