News Releases

IBBR Investigator to Lead $3.5M NIH-Funded Project to Study Immune Response to HIV-1


Funding will support novel vaccine design aimed at improving protective antibody responses

(Rockville, MD, April 24, 2019) Researchers at the Institute for Bioscience and Biotechnology Research (IBBR) recently received $3.5M from the National Institutes of Health (NIH) to advance understanding of the complex process by which the immune system produces highly specialized antibodies. 

IBBR Awarded NIH Grant to Investigate T Cell Biology Toward Development of Biotherapeutics


Findings may show how immune checkpoint LAG3 can be exploited to fight disease

(Rockville, MD, January 31, 2019) A team of investigators from the Institute for Bioscience and Biotechnology Research (IBBR) and the University of Pittsburgh recently received a $3.6M National Institutes of Health award to expand the scope of their T cell research involving LAG3 -- a well-known inhibitory receptor on T cells implicated in various cancers, as well as in the chronic infections associated with malaria and HIV.

IBBR Investigator to Lead $3.9M NIH-Funded Project to Develop Next-Generation HIV-1 Immunotherapy Agents


Multi-specific anti-HIV antibodies that neutralize almost all circulating HIV-1 viruses will be optimized to target persistent infection

(Rockville, MD, November 20, 2018) IBBR researchers recently received $3.9 million from the National Institutes of Health (NIH) to develop a multi-specific, single agent antibody therapeutic against HIV-1 to block virus infection and to clear the reservoir of HIV-infected cells from the body. 

IBBR Receives $1.2M NIH Award to Develop 3D Modeling Tool That Could Lead to New Immunotherapies


New computational tool supports the engineering and development of cancer immunotherapies by predicting how T cell receptors recognize and bind to their targets

(Rockville, MD, October 3, 2018)  The Institute for Bioscience and Biotechnology Research (IBBR) has been awarded a $1.2M National Institute of Health (NIH) grant to generate a robust modeling and design framework to predict the structures of T cell receptors (TCRs) from sequence, model antigen recognition, and design new TCRs with desired targeting capabilities that can be applied in therapies against... Read More

IBBR Researcher, Dr. Alexander Andrianov, Receives Funding for Two Collaborations


Collaborations will explore using two novel types of biofunctional synthetic macromolecules of the polyphosphazene (PPZ) family for exciting and very different applications. 

(Rockville, MD, October 17, 2018) Dr. Andrianov and his collaborator Dr. Svetlana Sukhishvili, of Texas A&M University, have demonstrated that layer-by-layer (LbL) assembly of amphiphilic (containing both hydrophilic and hydrophobic components) PPZs can be employed to create nano-structured fluorinated coatings that display superior biocompatibility. In another... Read More

Targeting HIV: Moving closer to a potential cure


Tri-specific antibody targets and neutralizes 99.5% of HIV-1 virus strains

(Rockville, MD, March 13, 2018) A team of researchers at IBBR, led by Dr. Yuxing Li, Associate Professor at the University of Maryland School of Medicine, Baltimore, and Principal Investigator at the Institute for Bioscience and Biotechnology Research (IBBR), Rockville, is showing how engineered multi-specific antibodies appear to be highly effective at preventing infection across a broad range of HIV-1 virus strains.

IBBR awarded DOE grant to investigate how to protect an emerging biofuel crop from disease


UMD researchers work to defend poplar trees – a promising resource for renewable and sustainable energy – from leaf rust and other diseases

(Rockville, MD, January 29, 2018)  The Institute for Bioscience and Biotechnology Research (IBBR) has been awarded a $1.1M U.S. Department of Energy grant to elucidate the mechanism of rust pathogenesis in poplar in an effort to engineer durable resistance for this important, second generation biofuel crop.  The collaborative, multidisciplinary research is led by Dr. Edward Eisenstein, IBBR Fellow and Associate Professor,... Read More

IBBR High School Intern Sarah Gao Named Regeneron Science Talent Search Finalist


Sarah Gao to Compete for Top Awards in Most Prestigious U.S. Science and Mathematics Competition for High School Seniors

(Rockville, MD., January 25, 2018) Sarah Gao, a senior at Montgomery Blair High School in Silver Spring, MD, and a research intern at the University of Maryland Institute for Bioscience and Biotechnology Research (IBBR) in Rockville, MD, has been named a finalist in the Regeneron Science Talent Search, the nation’s oldest and most prestigious science and math competition for high school seniors.

IBBR awarded NIH grant to investigate body’s T-cell mechanism of attack


New approaches hope to give researchers a glimpse into the cell’s “alert system” to fight tumors and viruses

(Rockville, MD, December 13, 2017)  A new research initiative by the Institute for Bioscience and Biotechnology Research (IBBR) and the University of Pittsburgh could finally uncover how T-cells—the “killer cells” that defend the body from microbes—are alerted to hazardous invaders in the body.  Funded by a $3.7 million grant from the National Institutes of Health (NIH), the research will be the first to combine X-ray crystallography and... Read More

IBBR Receives Grant to Explore Next Generation Multi-Specific Antibody Therapeutic: Next Step towards a Cure for HIV?


The goal is to develop and test a “first-in-class multi-specific antibody“, which could offer dramatic advantages over current treatments for AIDS patients, help eliminate hidden reservoirs of HIV, and potentially deliver on the promise of a long-awaited HIV cure.

(Rockville, MD, September 5, 2017) The Institute for Bioscience and Biotechnology Research (IBBR) has been awarded a $115,000 grant to further develop and commercialize a multi-specific antibody as a therapeutic for HIV.  The grant is funded under the Maryland Innovation Initiative (MII) by the Maryland... Read More