News Releases

Darwin Diaz Receives NIST Material Measurement Laboratory Accolade for Organizational Excellence


 

Darwin Diaz

October 4, 2021 - IBBR Staff Researcher Darwin Diaz was honored last month at the NIST Material Measurement Laboratory’s 2021 Accolades Gala for Organizational Excellence.  Darwin provides exceptional service and invaluable support to the joint NIST-Maryland research program at IBBR through outstanding management of the W.M. Keck/NIST X-ray Crystallography Core Facility, ranging from instrument installations and maintenance, to design and fabrication of custom pieces of research equipment.

 "We are very fortunate to have Darwin on our team.  He is all in for... Read More

IBBR Researchers Awarded $2.1M from the NIH to Develop Novel Designer Proteases - “SMART Molecules” That Attack the Drivers of Cancer and Other Diseases


Figure 1. Target sequence (QEEYSAM) in RAS and in the active site of a RAS-specific protease. a Structure of RAS with a bound GTP analog (PDB code 6Q21)5,6, highlighting the YSAM site in Switch 2. b RAS-specific protease based on an X-ray structure of 3BGO.pdb. Cognate sequence QEEYSAM-RD is modeled in the binding cleft. Substrate residues are denoted P1 through P5, numbering from the scissile bond toward the N-terminus of the substrate. The substrate amino acid on the leaving group side is denoted P1’.

... Read More

IBBR and REFI Announce New Travel Fellowship for 2021


September 27, 2021 - Applications are now open for a travel fellowship to support the success of graduate students and postdoctoral researchers working at the Institute for Bioscience and Biotechnology Research and the Robert E. Fischell Institute for Biomedical Devices.

Isoprene Pharmaceuticals, Inc. Co-Founded by IBBR Researcher, Receives $2M from NCI to Develop Oral Therapeutics for Triple Negative Breast Cancer


September 23, 2021 – Dr. Vincent Njar, IBBR Fellow and Professor, University of Maryland School of Medicine, co-founded Isoprene Pharmaceuticals, Inc. an early stage small molecule oncology company.  National Institute of Health’s (NIH) National Cancer Institute (NCI) has recently awarded Isoprene with a two-year $2M Small Business Innovation Research Direct-to-Phase II grant which will support ongoing advanced pre-clinical studies in their development of oral therapeutics for triple negative breast cancer (TNBC).  

TNBC accounts for approximately 10-15% of all breast cancers and... Read More

Congratulations to Tiffany Wong for a Successful Dissertation Defense


Tiffany Wong and Ed Eisenstein

August 24, 2021 – Please join us in congratulating Tiffany Wong for successfully defending her dissertation, “Investigation Into the Role of UVR8 in Balancing Growth and Acclimation to UV-B Radiation in Natural and Transgenic Populus Variants,” on July 30, 2021.  Wong has completed her course of study in the University of Maryland’s Plant Science and Landscape Architecture Program and fulfilled all of the requirements for the doctoral degree.  Her dissertation advisors were IBBR Fellow Edward Eisenstein (Associate Professor, Fischell Department of... Read More

Schiel Honored with Flemming Award


Dr. John Schiel

April 19, 2021 - Dr. John E. Schiel, NIST Research Chemist and IBBR Fellow, was awarded an Arthur S. Flemming on April 15, 2021 for his leading role in the development of a protein therapeutic measurements and standards program that works closely with the biopharmaceutical industry, regulators, and instrumentation companies.  Specifically, John led a team of NIST scientists in developing a world-first monoclonal antibody reference material, ... Read More

IBBR Fellow Vincent Njar Receives Inaugural Distinguished University Professor Designation


Dr. Vincent Njar

March 30, 2021 – Vincent Njar, PhD has been recognized with the designation of Distinguished University Professor by the University of Maryland, Baltimore (UMB). Dr. Njar is Head of Medicinal Chemistry Section, Center for Biomolecular Therapeutics, Institute for Bioscience and Biotechnology Research (IBBR) Fellow, and Professor, Department of Pharmacology, University of Maryland School of Medicine. This designation represents the highest appointment bestowed on a faculty member at UMB, recognizing excellence as well as impact and significant contribution to the nominee’s... Read More

European Patent for Method to Detect Protein Aggregation in a Biopharmaceutical Product Granted to IBBR Investigator Bruce Yu and Coworkers


Dr. Katharine Briggs (left), Dr. Bruce Yu (center) and Dr. Marc Taraban (right) in September 2019, shortly after they relocated from the University of Maryland, Baltimore campus to IBBR/USG.
Photo Credit: Katharine Briggs

February 26th 2021 – A European patent has been granted by the European Patent Office (EPO) for an invention assessing biopharmaceutical aggregation using magnetic resonance relaxometry to IBBR Fellow Bruce Yu, PhD, a Professor of Pharmaceutical Sciences at the University of Maryland, School of Pharmacy and Director of the School’s Bio- & Nano-Technology Center... Read More

Patent Pending for Novel Antimicrobial-Development Technology Stemming from IBBR Collaboration


CaptCpl-1 is a pneumococcal-specific endolysin composed of a GH25 enzyme active domain (EAD) and a cell wall binding domain (CBD). PlyCA contains two EADs, GyH and CHAP, but has no activity against pneumococcus. ClyX-1 is a chimeric endolysin, made from insertion of the Cpl-1 CBD in between the two PlyCA EADs. ClyX-1 not only has activity against pneumococcus, but its activity is 100-fold higher than Cpl-1, presumably due to synergistic activities of the two PlyCA EADs and specificity provided by the Cpl-1 CBD.

January 22, 2021 - A group of NIST and University of Maryland scientists has... Read More

Consortium Led by IBBR Fellow John Moult Fosters Advances in Protein Structure Prediction


Part of a plant virus glycoprotein. Computed structure blue, experiment magenta

January 19, 2021 -  Reports from the recent 14th Critical Assessment of Structure Prediction (CASP) community experiment show substantial progress in computing the structure of protein molecules. The three-dimensional structure of proteins provides key insights into understanding many aspects of their function, including disease mechanisms, the effect of genetic mutations, and facilitates the development of new therapeutics and vaccines. IBBR Fellow. Dr. John... Read More