In vivo Biology and Drug Testing

In Vivo Biology & Drug Testing (IVBDT)

The IVBDT program, directed by Dr. Danna B. Zimmer, Associate Professor, Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine, aids investigators with the selection of animal models and pharmacodynamic/pharmacokinetic parameters, including route of administration, schedule, dose, volume of distribution, half-life and biological endpoints, for in vivo studies.

CAPABILITIES

Animal Models

Neurological diseases (Alzheimer’s disease)
Cancer (Melanoma)
Signal transduction pathways (Ca2+ signaling)
De novo generation of new animal models for human diseases (transgenic and gene-targeted)
Colony management and animal husbandry
Aseptic non-surgical and sterile surgical procedures
Genotyping (Southern blot and PCR)

Cell-Based Pharmacokinetics/Pharmacodynamics

Cell permeability
Toxicity (LD50)
RNA/miRNA expression
Protein expression, localization, modification and interactions
Subcellular organization
Generation of genetically modified cell lines

In Vivo Pharmacokinetics

Bioavailablity
Distribution
Metabolism
Maximum tolerated dose (MTD)

In Vivo Pharmcodynamics

Behavior testing
Systemic health monitoring
Anatomical and histological pathology
RNA/miRNA expression and distribution
Protein expression, distribution, modification and interactions

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