IBBR Fellows

IBBR Scientists. Experts exploring new horizons. And advancing understanding.

IBBR unites distinguished scientists from the University of Maryland, College Park and the University of Maryland, Baltimore, and from the National Institute of Standards and Technology (NIST). Our Fellows come together across disciplines and institutions to discover tomorrow's biotechnology solutions.

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Name Profile
S. Saif Hasan
Department of Biochemistry and Molecular Biology

The Hasan laboratory focuses on elucidating the structural basis of biological trafficking by membrane protein complexes and of the hijacking of these host complexes during assembly of epidemic causing virus such as SARS-CoV-2. We use state-of-the-art single particle cryoEM and X-ray crystallography to perform atomic-level investigations of how viral proteins hijack host metabolic machinery. A central focus of our laboratory is the structural basis of molecular mimicry that drives coronavirus assembly.Our virus focused investigations will elucidate commonalities in how phylogenetically unrelated viruses exploit a few select host membrane proteins to achieve progeny propagation, an approach which could one day lead to the development of broad spectrum anti-virals.

Osnat Herzberg
Department of Chemistry and Biochemistry

Dr. Osnat Herzberg is a structural biologist interested in the relationship between the function and structure of proteins and how protein-ligand interactions can guide drug discovery. The Herzberg lab uses X-ray crystallography and other biophysical, biochemical, and cellular approaches to better understand various experimental systems.

Jeffrey Hudgens
Biomolecular Measurement Division

Dr. Jeffrey Hudgens investigates the precision of hydrogen-deuterium exchange mass spectrometry (HDX-MS) and its application to the measurement of protein-ligand and glycoprotein-ligand interactions, the dynamical structures of mAbs, lipid-protein complexes, and membrane protein interactions. In addition to these fundamental determinations of the relationship between biomolecular structure and function, Dr. Hudgens also invents new apparatus and methods that improve HDX-MS methodology, especially as related to biopharmaceutical analysis. These improvements and insights will enable HDX-MS to be used in comparability studies of innovator and biosimilar drugs, thus advancing biopharmaceutical development and regulation.