IBBR/NIST BMD Seminar: “Engineering next-generation nanodiscs for membrane proteins studies”
Event Type:
IBBR Seminar Series
Contact Person:
Nicole Tenly
Event Info
Date:
Tuesday, November 30 2021 - 11:00am to 12:00pm
Location:
Virtual
Event Details
Speaker:
Mahmoud Nasr
Affiliation:
Harvard
Description:
We will present modular methods to produce covalently circularized and DNA-Corralled nanodiscs and show some of their applications.
We will present the cryo-EM structures of lipid bilayer-bound complexes of neurotensin receptor, and G protein heterotrimer in two conformational states. The structures were determined without any stabilizing antibodies/nanobodies, and thus provide a native-like platform for understanding the structural basis of GPCR-G protein complex formation.
Add to Calendar