NIST BMD/IBBR Seminar: Extracting Information from LC-MS/MS Data to Support Biopharmaceutical Development

Mass spectrometry plays an important role at every stage of biopharmaceutical development. With the advancement of modern instrumentations, collecting high-quality data becomes routine, while translating data into results becomes the new bottleneck. This presentation describes a battery of computational methods we have developed over the past 20 years to extract information from LC-MS/MS data, together with a few real-world applications. Methods to be discussed include component detection, mass determination, retention time alignment, peptide identification based on theoretical MS/MS prediction, and quantitation. Method for complete extraction of protein dynamics information from H/D exchange data will also be discussed.

Meeting link:

https://umd.webex.com/umd/j.php?MTID=m201486642d5d80ecb40562b3ae7bacc0

Meeting number:

120 684 5940

Password:

M48dxTjcMa3