Brian Pierce Appointed Director of the UMD Biological Sciences (BISI) Computational Biology, Bioinformatics, and Genomics (CBBG) Graduate Program
We are delighted to congratulate Dr. Brian Pierce, IBBR Fellow and Associate Professor in the Department of Cell Biology and Molecular Genetics at University of Maryland, College Park, on his appointment as Director of the UMD Biological Sciences (BISI) Computational Biology, Bioinformatics, and Genomics (CBBG) graduate program, effective July 1....
Researchers Uncover How Key Cell Proteins Interact with Implications for Cancer Treatment
How do cells coordinate activities between their insides and their outside? A new study published in Science Advances by researchers from the University of Maryland (UMD), the National Institute of Standards and Technology (NIST), and the City of Hope Medical Center provides a molecular-level answer. The research uncovers novel insights...
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IBBR’s Dr. Eisenstein Elected President of the American Society for Biochemistry and Molecular Biology
IBBR proudly congratulates Dr. Edward Eisenstein on his election as president of the American Society for Biochemistry and Molecular Biology (ASBMB), a prestigious scientific society with nearly 12,000 members worldwide. ASBMB fosters a global community of researchers committed to advancing the molecular life sciences. Dr. Eisenstein will begin his four-year...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
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IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Seminar: Kenneth Marcus, Clemson University
Monday, September 22, 2025 - 11:00am
Recent Publications
How Electric Field Remodels the Nanofibril Structure of Chitosan Hydrogels: the Role of Dewetting During Electro-Assembly.
Electrofabrication has emerged as a versatile technique for creating complex functional materials from self-assembling biopolymers such as chitosan and collagen; however, a molecular-level...
Genetically-programmed Hypervesiculation of Lactiplantibacillus plantarum Increases Production of Bacterial Extracellular Vesicles with Therapeutic Efficacy in a Preclinical Inflammatory Bowel Disease Model.
Inflammatory bowel diseases (IBD) affect over 6 million people globally and current treatments achieve only 10-20% rates of durable disease remission. Bacterial extracellular vesicles (BEVs) from...
de novo Fabrication of Dense Collagen Matrices with Patterned Hierarchical Structures for Corneal Stromal Tissue Repair.
Collagen is a versatile biological building block that is guided by extracellular cues to self-assemble into diverse hierarchical structures that perform various tissue functions. Here, the use of...
Top-Down Scoring of Spectral Fitness by Image Analysis for Protein Structure Validation.
Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for protein structure determination, but traditional approaches require extensive manual assignment of hundreds to thousands...
Measuring oxidative stress by the iridium reducing capacity assay (Ir-RCA).
Oxidative stress appears to act globally and span body systems (e.g., nervous, immune, and endocrine). Currently, there is no single, generally-accepted measurement of oxidative stress. Many...