New Study Uncovers Temperature-Driven Mechanism in Metamorphic Proteins
Dr. John Orban, IBBR Fellow and a Professor in the Department of Chemistry and Biochemistry at University of Maryland and his co-author Andy LiWang, a Professor of Chemistry and Biochemistry at the University of California, Merced, recently published a Perspectives article “Unveiling the cold reality of metamorphic proteins” in PNAS...
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Structural Biology Day at IBBR
The Institute for Bioscience and Biotechnology Research (IBBR) invites you to participate in our second biennial Structural Biology Day on Wednesday, May 7, 2025 at our facility in Rockville, Maryland. The event will feature research talks in various aspects of structural biology, including cryoelectron microscopy, X-ray crystallography, mass spectrometry, diffraction...
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Manghrani Presents at Inaugural Nucleic Acids Therapeutics Meeting in India
Akanksha Manghrani, a UMD Postdoctoral Research Associate, working in the NIST-IBBR biomanufacturing program under the direction of Dr. Robert Brinson, delivered a talk and presented a poster at the First Regional Nucleic Acids Therapeutics Meeting in Bengaluru, India organized by the Oligonucleotide Therapeutics Society (OTS). The aim of the regional...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
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IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
BMD Staff Seminar A. Zuber/ S. Aalbers, .04/.06
Tuesday, March 25, 2025 - 11:00am
Research in Progress Seminar: Jaekyun Jeon
Monday, March 31, 2025 - 11:00am
BMD Staff Seminar C. Meuse/ E. Romsos, .03/.06
Tuesday, April 1, 2025 - 11:00am
Recent Publications
3D nanoprinting of PDMS microvessels with tailored tortuosity and microporosity via direct laser writing.
Microvessels (e.g., capillaries) are ubiquitous throughout human anatomy, yet recreating their three-dimensional (3D) microfluidic and architectural sophistication at biologically accurate length...
Unveiling the cold reality of metamorphic proteins.
Metamorphic proteins switch reversibly between two differently folded states under a variety of environmental conditions. Their identification and prediction are gaining attention, but the...
Sleep Health and White Matter Integrity in the UK Biobank.
Many people experience impaired sleep health, yet knowledge about its neurobiological correlates is limited. As previous studies have found associations between white matter integrity and several...
Genomic characterization of the HER2-enriched intrinsic molecular subtype in primary ER-positive HER2-negative breast cancer.
ER-positive/HER2-negative (ERpHER2n) breast cancer classified as PAM50 HER2-enriched (ERpHER2n-HER2E) represents a small high-risk patient subgroup. In this study, we investigate genomic,...
Increasing the Accuracy and Robustness of the CHARMM General Force Field with an Expanded Training Set.
Small molecule empirical force fields (FFs), including the CHARMM General Force Field (CGenFF), are designed to have wide coverage of organic molecules and to rapidly assign parameters to...