.png)
Standardizing Dual-Reporter Gene Expression: The MINDR Guidelines for Reliable Data Interpretation
Dual gene expression reporter systems are widely used molecular biology tools that encode two different proteins within a synthetic mRNA sequence. Such systems play a crucial role in studying diseases, drug therapies, and cellular mechanisms. In a significant advancement, leading researchers in the field have published “Guidelines for minimal reporting...
%20(1).jpg)
Congratulations to Daniel Kemboi for a Successful Dissertation Defense
IBBR proudly congratulates Daniel Kemboi for successfully defending his PhD dissertation on “The Molecular Basis for Gamma Phage Targeting” on March 11, 2025. Kemboi will complete his coursework and fulfill the requirements for the doctoral degree this month. His research, done under Dr. Daniel Nelson (IBBR Fellow), explores how bacteriophage...
Ibrahim Boyenle Receives G. Forrest Woods Memorial Scholarship and Outstanding Presentation Award at the Regional NOBCChE Meeting
Please join us in congratulating Ibrahim Boyenle, a 3rd year PhD student in Dr. Yanxin Liu’s lab (IBBR Fellow) on receiving the UMD Department of Chemistry and Biochemistry's G. Forrest Woods Memorial Scholarship. The annual award provides funds towards the educational expenses of an outstanding undergraduate or graduate student in...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Research in Progress Seminar: Veronika Szalai
Monday, June 9, 2025 - 11:00am
BMD Staff Seminar S. Mishra/ A. Tran, .03/.04
Tuesday, June 10, 2025 - 11:00am
NIST Group Meeting: Robert Allsopp
Wednesday, June 11, 2025 - 11:00am
Recent Publications
Native-like soluble E1E2 glycoprotein heterodimers on self-assembling protein nanoparticles for hepatitis C virus vaccine design.
UNLABELLED
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma worldwide. E1E2-based HCV vaccine development has been hindered by the...
Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers.
Global elimination of hepatitis C virus (HCV) will require an effective cross-genotype vaccine. The HCV E2 envelope glycoprotein is the main target of neutralizing antibodies but also contains...
Evaluation of Alphafold modeling for elucidation of nanobody-peptide epitope interactions.
Models of Ab-antigen complexes can be used to understand interaction mechanisms and for improving affinity. This study evaluates the use of the protein structure prediction algorithm AlphaFold...
The crystal structure and biochemical analyses of Escherichia coli YqgF illuminate its diverse functions.
The Escherichia coli yqgF gene product is essential for bacterial growth and to confer resistance to multiple antimicrobial agents. Furthermore, additional evidence suggests that YqgF, a RuvC...
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV.
Anti-HIV envelope broadly neutralizing antibodies (bnAbs) are alternatives to conventional antiretrovirals with the potential to prevent and treat infection, reduce latent reservoirs, and/or...