%20(1).jpg)
Congratulations to Daniel Kemboi for a Successful Dissertation Defense
IBBR proudly congratulates Daniel Kemboi for successfully defending his PhD dissertation on “The Molecular Basis for Gamma Phage Targeting” on March 11, 2025. Kemboi will complete his coursework and fulfill the requirements for the doctoral degree this month. His research, done under Dr. Daniel Nelson (IBBR Fellow), explores how bacteriophage...
Ibrahim Boyenle Receives G. Forrest Woods Memorial Scholarship and Outstanding Presentation Award at the Regional NOBCChE Meeting
Please join us in congratulating Ibrahim Boyenle, a 3rd year PhD student in Dr. Yanxin Liu’s lab (IBBR Fellow) on receiving the UMD Department of Chemistry and Biochemistry's G. Forrest Woods Memorial Scholarship. The annual award provides funds towards the educational expenses of an outstanding undergraduate or graduate student in...
Uncovering the Split ISR Pathway: A New Understanding of Cellular Stress and Its Implications for Treating Genetic Diseases
A recent study has challenged the long-standing understanding of how our cells respond to stress. For decades, scientists believed that cells react to various stressors—such as starvation, infection by pathogens, heat, and iron deficiency—through a unified pathway known as the Integrated Stress Response (ISR). The ISR functions by modulating protein...
About IBBR
IBBR is a joint research enterprise of the University of Maryland, College Park, the University of Maryland, Baltimore, and the National Institute of Standards and Technology.
IBBR leverages state-of-art integrative methods for bioanalytical, biophysical and structural characterization of biomolecules: cryo-electron microscopy, nuclear magnetic resonance, x-ray crystallography, small angle neutron and x-ray scattering and mass spectrometry.
IBBR researchers seek to advance therapeutic development, biomanufacturing, and state-of-the-art measurement technologies, to support accelerated delivery of safe and effective medicines to the public.
IBBR is a major initiative and supported in part by the University of Maryland Strategic Partnership: MPowering the State (MPower) , an initiative designed to achieve innovation and impact through collaboration.
Connecting
IBBR Commons
Sophisticated state-of-the-art instrumentation and facilities, and in-house expertise located in shared space and dedicated to advance research, support collaboration and foster innovation of methods. Instrumentation and facilities include tools for high-resolution structural biology, bioanalytical and biophysical measurement, protein engineering and cell culture, advanced computation including artificial intelligence and deep learning methods, and general laboratory services. These capabilities and advanced training are available to IBBR scientists and collaborators.
IBBR Postdoc Program
The IBBR Postdoc Program (IPP) focuses on collaborative research involving basic science and technology development that advances therapeutic development, vaccine development, and biomanufacturing. IPP Fellow project teams are designed with a combination of the IPP Fellow career goals and priorities of project mentors who can be from academic, government, and/or industrial laboratories throughout the University of Maryland, NIST and the I-270 corridor.
NMRPipe
IBBR is home to NMRPipe, a popular collection of programs and scripts for manipulating multidimensional Nuclear Magnetic Resonance (NMR) data. The use of NMRPipe is noted in roughly 40% of all NMR structures accepted into the Protein Data Bank.
Upcoming Events
Seminar: David Thompson, Purdue University
Tuesday, May 27, 2025 - 11:00am
NIST Group Meeting; Harsha Kolanupaka
Wednesday, May 28, 2025 - 11:00am
NIST Group Meeting; Akanksha Manghrani
Wednesday, June 4, 2025 - 11:00am
Recent Publications
N-Hydroxypipecolic acid and salicylic acid play key roles in autoimmunity induced by loss of the callose synthase PMR4.
In Arabidopsis thaliana, the POWDERY MILDEW RESISTANT4 (PMR4)/GLUCAN SYNTHASE LIKE5 (GSL5) callose synthase is required for pathogen-induced callose deposition in cell wall defense. Paradoxically,...
Development and Characterization of the NISTCHO Reference Cell Line.
Well-characterized reference materials enable successful collaborations within the scientific community by establishing common reagents for benchmarking studies and reducing the barriers to...
The Future of Insomnia Research-There's Still Work to Be Done.
Insomnia Disorder (ID) is a highly debilitating disorder affecting up to 10% of the general population. In recent years, the number of studies in this area has increased rapidly, resulting in a...
Glycoengineering of the hepatitis C virus E2 glycoprotein leads to improved biochemical properties and enhanced immunogenicity.
An effective vaccine against hepatitis C virus (HCV) must elicit the production of broadly neutralizing antibodies (bnAbs) reproducibly against the E1E2 glycoprotein complex. Little is known about...
High-Throughput Ligand Dissociation Kinetics Predictions Using Site Identification by Ligand Competitive Saturation.
The dissociation or off rate, koff, of a drug molecule has been shown to be more relevant to efficacy than affinity for selected systems, motivating the development of predictive computational...